A 58-year-old man with AML presents with fever and rigors 2 days after third chemotherapy cycle. Central venous line in situ.
Observations: HR 118, RR 24, SpO₂ 96%, BP 94/62, Temp 38.6°C. Neutrophils 0.3 × 10⁹/L, CRP 186, lactate 2.8, CXR clear.
What is the most appropriate immediate management?
A
Await blood culture results before starting antibiotics
B
Oral ciprofloxacin and discharge with haematology follow-up
C
IV piperacillin-tazobactam within 1 hour, cultures, sepsis 6
D
IV vancomycin only targeting central line infection
E
G-CSF immediately and defer antibiotics 24 hours